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MCAS, the Vagus Nerve, and the Cholinergic Anti-Inflammatory Reflex
MCAS mast cell histamine

MCAS, the Vagus Nerve, and the Cholinergic Anti-Inflammatory Reflex

Mast cell activation is not just an allergy problem. It is a failure of the vagal brake on innate immunity — and the cholinergic anti-inflammatory pathway is one of the most promising therapeutic levers.

By UltraSkool Research Team May 10, 2026